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Automated Liquid Handling

Automated liquid handling is used in automation of laboratories systems. The most important parameters in liquid handling are dispense velocity and precision, which are translated into hardware by our experienced engineers. With our in-house software department reliability as well as reproducibility of results are ensured.

The rheological properties of a liquid determine the dispense velocity and precision. This affects the required hardware chosen for processing samples of the specific application. Other properties that can be handled are polarity (through magnetic interaction or electrical charge), hydrophobicity, high or low surface tension, solubility, temperature, vapor pressure, and air pressure.

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Technical Advantages

With conductivity measurements Zinsser Analytic detects the liquid levels of different liquids which enables fully automated liquid-liquid-extractions of liquids that are insoluble in each other. Liquid level detection is also possible with special carbonized disposable pipetting tips.
Pipetting tips are either chosen from a variety of non-disposable tips with specific properties for each application – e.g. stainless steel, piercing, PTFE coated, filtration, heatable, ceramic coated, multiple channel tips etc. – disposable tips of various volumes (10 µL up to 10 mL, accuracy ± 1%) or from special glass or disposable viscous media tips (100 µL up to 50 mL, accuracy ± 0.5-3%).
Every non-disposable tip is also available as small volume tip, with a reduced diameter for a precise pipetting of smaller volumes.

Low surface tension is a tricky property to handle, since those liquids tend to drip from the pipetting tips. Zinsser Analytic developed several techniques to avoid this dripping and to safely transfer the full required volumes from A to B. For the opposite case of a high surface tension Zinsser Analytic provides solutions as well.
Also the pH value, temperature, polarity and changed pressure can cause undesired effects like precipitation or forming of emulsions, which can be retransferred into solution by several techniques, e.g. ultrasonication, vortexing, heating, etc.

Additional Advantages

Using conductivity measurements, Zinsser Analytic’s Liquid Handling platform detects the liquid levels of different liquids. This enables fully automated liquid-liquid-extractions (LLEs), which applies two different solvents that are insoluble with each other. Liquid level detection is also possible with special carbonized disposable pipetting tips.
Pipetting tips are either chosen from a variety of non-disposable or disposable tips. Non-disposable ones are made from specific properties for each application, for example, stainless steel, piercing, PTFE coated, filtration, electrically heated, ceramic coated, multiple channel tips, etc. We offer disposable tips of various volumes (10 µL up to 10 mL, accuracy ± 1%). They are made from special glass, or from disposable viscous media tips (100 µL up to 50 mL, accuracy ± 0.5-3%).

Every non-disposable tip is also available as a small volume tip. It has a reduced diameter for precise pipetting of smaller volumes.
Low surface tension is a tricky property to handle, since those liquids tend to drip from the pipetting tips. Zinsser Analytic developed several techniques to avoid dripping and to safely transfer volumes from A to B. We also provide solutions for high surface tension.
The pH value, temperature, polarity and changes in pressure can cause undesired side effects like precipitation or forming of emulsions. These can be resolubilized into solution by several techniques, for example, ultrasonication, vortexing, heating, etc.

Applications

Pipetting of diverse volumes from A to B for precise and reliable results
Whole liquid handling processes can be carried out including shaking, heating, reaction time etc. in between.
Combination with gripping tools for rack and vial transport possible as well as combination with powder dispense probes and handling options for viscous media
Many industry segments are addressed: chemical, biochemical, pharmaceutical, agrochemical industry etc.

Picture of Dispense from a stainless steel cup

Software

Windows-based WinLissy® software:

Allows full control of your automation system
Can adapt to the most demanding lab automation requirements
Provides Intuitive User Interface
Allows you to set up the sample workup
Able to communicate with third party devices (analyzers, chillers, etc.)
Gives full control in simulating lab testing methods
Has ability to schedule lab tests
Provides a thorough audit trail
Control specific devices
Import data from files and databases such as SQL, Excel, CSV, etc.
Integrates with other software, importing files from databases and exporting results in various standardized formats like CSV, SQL, XML, and Oracle file formats
Ability to adapt to any pipetting requirements, may it be small or large volumes in addition to any precision requirement

Downloads

c23296-nmr-sample-prep-brochure_german_web

Automated Liquid Handling

Technical Advantages

Additional Advantages

Applications

Software

Downloads

Liquid Handling Only Brochure-DE

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